Name
Abstract | ||
|---|---|---|
Recent comparative studies indicate surprising flexibility of regulatory systems in bacteria. These systems can be analyzed on several levels, and I plan to consider two of them. At the level of regulon evolution, one can attempt to characterize the evolution of regulon content formed by loss, gain and duplications of regulators and regulated genes, as well as gain and loss of individual regulatory sites and horizontal gene transfer. At the level of transcription factor families, one can study co-evolution of DNA-binding proteins and the motifs they recognize. While this area is not yet ripe for fully automated analysis, the results of systematic comparative studies gradually start to coalesce into an understanding of how bacteria regulatory systems evolve. |
Year | DOI | Venue |
|---|---|---|
2009 | 10.1007/978-3-642-01551-9_1 | ISBRA |
Keywords | Field | DocType |
bacteria regulatory system,invited keynote talk,systematic comparative study,regulatory system,regulon content,dna-binding protein,recent comparative study,regulatory systems,horizontal gene transfer,regulon evolution,automated analysis,individual regulatory site,comparative genomics,comparative study,dna binding protein,transcription factor,transcription factor binding site | Regulon,Gene,Binding site,Biology,T-box,Horizontal gene transfer,Comparative genomics,Bacteria,Bioinformatics,Transcription factor | Conference |
Volume | ISSN | Citations |
5542 | 0302-9743 | 0 |
PageRank | References | Authors |
0.34 | 1 | 9 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| M S Gelfand | 1 | 343 | 71.47 |
| Alexei E. Kazakov | 2 | 25 | 2.18 |
| Yuri D. Korostelev | 3 | 0 | 0.34 |
| Olga N. Laikova | 4 | 15 | 1.94 |
| Andrei A. Mironov | 5 | 0 | 0.34 |
| Alexandra B. Rakhmaninova | 6 | 0 | 0.34 |
| Dmitry A. Ravcheev | 7 | 34 | 1.79 |
| Dmitry A. Rodionov | 8 | 33 | 6.59 |
| Alexei G. Vitreschak | 9 | 0 | 0.34 |