Name
Abstract | ||
|---|---|---|
There have been several studies on the micro-inversions between human and chimpanzee, but there are large discrepancies among their results. Furthermore, all of them rely on alignment procedures or existing alignment results to identify inversions. However, the core alignment procedures do not take very small inversions into consideration. Therefore, their analyses cannot find inversions that are too small to be detected by a classic aligner. We call such inversions pico-inversions.We re-analyzed human-chimpanzee alignment from the UCSC Genome Browser for micro-inplace-inversions and screened for pico-inplace-inversions using a likelihood ratio test. We report that the quantity of inplace-inversions between human and chimpanzee is substantially greater than what had previously been discovered. We also present the software tool PicoInversionMiner to detect pico-inplace-inversions between closely related species.Software tools, scripts and result data are available at http://faculty.cs.niu.edu/~hou/PicoInversion.html.mhou@cs.niu.edu. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1093/bioinformatics/btr566 | Bioinformatics |
Keywords | Field | DocType |
software tool,small inversion,alignment procedure,ucsc genome browser,core alignment procedure,classic aligner,alignment result,inversions pico-inversions,software tool picoinversionminer,chimpanzee alignment,genome,sequence alignment,chromosome inversion | Genome,Sequence alignment,Likelihood-ratio test,Computer science,Chromosomal inversion,Genome browser,Inversion (meteorology),Software,Bioinformatics,Scripting language | Journal |
Volume | Issue | ISSN |
27 | 23 | 1367-4811 |
Citations | PageRank | References |
0 | 0.34 | 4 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Minmei Hou | 1 | 20 | 2.74 |
| Ping Yao | 2 | 0 | 0.34 |
| Angela Antonou | 3 | 0 | 0.34 |
| Mitrick A Johns | 4 | 0 | 0.34 |