Title
Mining of cis-Regulatory Motifs Associated with Tissue-Specific Alternative Splicing
Abstract
Alternative splicing (AS) is an important post-transcriptional mechanism that can increase protein diversity and affect mRNA stability and translation efficiency. Many studies targeting the regulation of alternative splicing have focused on individual motifs; however, little is known about how such motifs work in concert. In this paper, we use distribution-based quantitative association rule mining to find combinatorial cis -regulatory motifs and to investigate the effect of motif pairs. We also show that motifs that occur in motif pairs typically occur in clusters.
Year
DOI
Venue
2009
10.1007/978-3-642-01551-9_26
ISBRA
Keywords
Field
DocType
protein diversity,mrna stability,combinatorial cis,tissue-specific alternative splicing,quantitative association rule mining,cis-regulatory motifs associated,regulatory motif,motif pair,individual motif,translation efficiency,important post-transcriptional mechanism,alternative splicing,association rule mining
Text mining,Computer science,Alternative splicing,Motif (music),Association rule learning,Bioinformatics
Conference
Volume
ISSN
Citations 
5542
0302-9743
2
PageRank 
References 
Authors
0.39
37
4
Name
Order
Citations
PageRank
Jihye Kim120.73
Sihui Zhao241.81
Brian E. Howard3264.24
Steffen Heber421922.88