Title
Demand-Driven Mixture Preparation and Droplet Streaming using Digital Microfluidic Biochips
Abstract
In many biochemical protocols, such as polymerase chain reaction, a mixture of fluids in a certain ratio is repeatedly required, and hence a sufficient quantity of the mixture must be supplied for assay completion. Existing sample-preparation algorithms based on digital microfluidics (DMF) emit two target droplets in one pass, and costly multiple passes are required to sustain the emission of the mixture droplet. To alleviate this problem, we design a streaming engine on a DMF biochip, which optimizes droplet emission depending on the demand and available storage. Simulation results show significant reduction in latency and reactant usage for mixture preparation.
Year
DOI
Venue
2014
10.1145/2593069.2593119
Design Automation Conference
Keywords
Field
DocType
drops,lab-on-a-chip,microfluidics,DMF biochip,biochemical protocols,demand-driven mixture preparation,digital microfluidic biochips,digital microfluidics,droplet emission,droplet streaming,polymerase chain reaction,sample-preparation algorithms,streaming engine
Digital microfluidics,Biochip,Latency (engineering),Computer science,Microfluidics,Electronic engineering,Drop (liquid),Demand driven
Conference
ISSN
Citations 
PageRank 
0738-100X
5
0.41
References 
Authors
15
5
Name
Order
Citations
PageRank
Sudip Roy130929.71
Srijan Kumar232624.97
Partha Pratim Chakrabarti36411.53
Bhargab B. Bhattacharya4848118.02
K Chakrabarty58173636.14