Paper Info
Title
Cerebral blood flow and BOLD responses to a memory encoding task: a comparison between healthy young and elderly adults.
Abstract
Functional magnetic resonance imaging (fMRI) studies of the medial temporal lobe have primarily made use of the blood oxygenation level dependent (BOLD) response to neural activity. The interpretation of the BOLD signal as a measure of medial temporal lobe function can be complicated, however, by changes in the cerebrovascular system that can occur with both normal aging and age-related diseases, such as Alzheimer's disease. Quantitative measures of the functional cerebral blood flow (CBF) response offer a useful complement to BOLD measures and have been shown to aid in the interpretation of fMRI studies. Despite these potential advantages, the application of ASL to fMRI studies of cognitive tasks and at-risk populations has been limited. In this study, we demonstrate the application of ASL fMRI to obtain measures of the CBF and BOLD responses to the encoding of natural scenes in healthy young (mean 25 years) and elderly (mean 74 years) adults. The percent CBF increase in the medial temporal lobe was significantly higher in the older adults, whereas the CBF levels during baseline and task conditions and during a separate resting-state scan were significantly lower in the older group. The older adults also showed slightly higher values for the BOLD response amplitude and the absolute change in CBF, but the age group differences were not significant. The percent CBF and BOLD responses are consistent with an age-related increase in the cerebral metabolic rate of oxygen metabolism (CMRO2) response to memory encoding.
Year
DOI
Venue
2007
10.1016/j.neuroimage.2007.05.024
NeuroImage
Keywords
Field
DocType
aging,oxygen,memory,magnetic resonance imaging,age groups,cerebral blood flow,resting state,metabolic rate
Developmental psychology,Functional magnetic resonance imaging,Elementary cognitive task,Neural activity,Psychology,Response Amplitude,Cerebral blood flow,Absolute Change,Magnetic resonance imaging,Temporal lobe
Journal
Volume
Issue
ISSN
37
2
1053-8119
Citations 
PageRank 
References 
17
1.07
14
Authors
5
Name
Order
Citations
PageRank
Khaled Restom143824.27
Katherine J. Bangen2372.60
Mark W. Bondi3382.99
Joanna E Perthen41398.49
Thomas T Liu5102276.03