Name
Abstract | ||
|---|---|---|
Protein-protein interaction and gene regulatory networks are likely to be locked in a state corresponding to a disease by the behavior of one or more bistable circuits exhibiting switch-like behavior. Sets of genes could be over-expressed or repressed when anomalies due to disease appear, and the circuits responsible for this over- or under-expression might persist for as long as the disease state continues. This paper shows how a large-scale analysis of network bistability for various human cancers can identify genes that can potentially serve as drug targets or diagnosis biomarkers. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1371/journal.pcbi.1000851 | PLOS COMPUTATIONAL BIOLOGY |
Keywords | Field | DocType |
drug targeting,gene regulatory networks,computational biology,drug discovery,gene expression profiling,signal transduction,protein protein interaction,gene regulatory network | Disease,Drug discovery,Bistability,Gene,Biology,Biomarker (medicine),Bioinformatics,Genetics,Gene regulatory network,Gene expression profiling,DNA microarray | Journal |
Volume | Issue | ISSN |
6 | 7 | 1553-7358 |
Citations | PageRank | References |
7 | 0.59 | 6 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Tetsuya Shiraishi | 1 | 8 | 0.95 |
| Shinako Matsuyama | 2 | 14 | 2.24 |
| Hiroaki Kitano | 3 | 3515 | 539.37 |