Title | ||
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Multiscale interactions between chemical and electric signaling in LTP induction, LTP reversal and dendritic excitability |
Abstract | ||
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Synaptic plasticity leads to long-term changes in excitability, whereas cellular homeostasis maintains excitability. Both these processes involve interactions between molecular events, electrical events, and network activity. Here I explore these intersections with a multilevel model that embeds molecular events following synaptic calcium influx into a multicompartmental electrical model of a CA1 hippocampal neuron. I model synaptic plasticity using a two-state (bistable) molecular switch that controls glutamate receptor insertion into the post-synaptic density. I also model dendritic activation of the MAPK signaling pathway, which in turn phosphorylates and inactivates A-type potassium channels. I find that LTP-inducing stimuli turn on individual spines and raise dendritic excitability. This increases the amount of calcium that enters due to synaptic input triggered by network activity. As a result, LTD is now induced in some synapses. Overall, this suggests a mechanism for cellular homeostasis where strengthening of some synapses eventually balances out through weakening of a possibly overlapping set of other synapses. Even in this very narrow slice of cellular events, interesting system properties arise at the interface between multiple scales of cellular function. |
Year | DOI | Venue |
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2011 | 10.1016/j.neunet.2011.05.001 | Neural Networks |
Keywords | Field | DocType |
Multiscale model,Synaptic plasticity,Long-term potentiation,Homeostasis,Receptor trafficking,MAPK | Long-term potentiation,Synapse,Neuroscience,Mathematical optimization,Synaptic augmentation,Synaptic plasticity,Neuron,Synaptic fatigue,Metaplasticity,Mathematics,LTP induction | Journal |
Volume | Issue | ISSN |
24 | 9 | 0893-6080 |
Citations | PageRank | References |
3 | 0.51 | 2 |
Authors | ||
1 |
Name | Order | Citations | PageRank |
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Upinder S Bhalla | 1 | 333 | 49.60 |