Name
Title | ||
|---|---|---|
The Adaptive Evolution Database (Taed): A Phylogeny Based Tool For Comparative Genomics |
Abstract | ||
|---|---|---|
From 138 662 embryophyte (higher plant) and 348 142 chordate genes, 4216 embryophyte and 15 452 chordate gene families were generated. For each of these gene families, multiple sequence alignments, phylogenetic trees, ratios of non-synonymous to synonymous nucleotide substitution rates (K-a/K-s), mappings from gene trees to the NCBl taxonomy and structural links to solved three-dimensional protein structures in the Protein Data Bank (PDB) with Grantham-weighted mutational factors were all calculated. Of the 'gene family trees', 173 embryophyte and 505 chordate branches show K-a/K-s much greater than 1 and are candidates for functional adaptation. The calculated information is available both as a gene family database and as a phylogenetically indexed resource, called 'The Adaptive Evolution Database' (TAED), available at http://www.bioinfo.no/tools/TAED. |
Year | DOI | Venue |
|---|---|---|
2005 | 10.1093/nar/gki090 | NUCLEIC ACIDS RESEARCH |
Keywords | Field | DocType |
indexation,genomics,genome,genetics,database management systems,multiple sequence alignment,protein data bank,phylogeny,comparative genomics,gene family,three dimensional,computer graphics,sequence alignment | Sequence alignment,Genome,Phylogenetic tree,Biology,Comparative genomics,Genomics,Genetics,Protein Data Bank,Phylogenetics,Gene family,Database | Journal |
Volume | Issue | ISSN |
33 | Database issue | 0305-1048 |
Citations | PageRank | References |
5 | 0.79 | 7 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Christian Roth | 1 | 5 | 0.79 |
| Matthew J. Betts | 2 | 21 | 4.53 |
| Pär Steffansson | 3 | 5 | 0.79 |
| Gisle Sælensminde | 4 | 36 | 4.23 |
| David A Liberles | 5 | 48 | 2.96 |