Title
Multiphase Level Set Model with Local K-means Energy for Histology Image Segmentation
Abstract
In this paper we present a multiphase level set model for histology image segmentation. Global K-means energy is weighted by a Gaussian kernel to cluster image pixels in local neighborhoods. We group these local clusters into different source classes using a multiphase level set model to produce the final segmentation results. Our energy functional is formulated as the integral of local K-means energies across the entire image. Unlike current local region-based active contour methods that update the pixel neighborhood distributions (e.g. local intensity means) in each iteration, we estimate these statistics before contour evolution for more efficient computation. In addition, such pre-derived local intensity distributions enable a model without initial contour selection, i.e., the level set functions can be initialized with a random constant instead of a distance map. In this way our model ameliorates the initialization sensitivity problem of most active contour methods. Experiments on the National Cancer Institute ALTS histology images show the improved performance of our approach over standard multithresholding and K-means clustering, as well as state-of-the-art active contours, mean shift clustering, and Markov random field-based pixel labeling methods.
Year
DOI
Venue
2011
10.1109/HISB.2011.35
HISB
Keywords
Field
DocType
local region based active contour methods,local intensity,level set functions,pattern clustering,biomedical optical imaging,gaussian kernel,pixel neighborhood distribution,histology image,pre-derived local intensity distribution,computational geometry,image segmenation,local intensity distributions,multiphase level set model,energy functional,local neighborhood,image classification,alts histology images,image pixel clustering,contour evolution,local cluster,local k-means energy,multiphase level set,histology image segmentation,source classes,mean shift clustering,markov random field based pixel labeling methods,histology,national cancer institute,active contour method,initial contour selection,medical image processing,local region-based active contour,mathematical model,computational modeling,image segmentation,k means,level set,labeling
Active contour model,k-means clustering,Pattern recognition,Markov random field,Level set,Image segmentation,Distance transform,Artificial intelligence,Mean-shift,Cluster analysis,Mathematics
Conference
ISBN
Citations 
PageRank 
978-0-7695-4407-6
4
0.45
References 
Authors
12
4
Name
Order
Citations
PageRank
Lei He1295.87
L. Rodney Long253456.98
Sameer Antani31402134.03
George R. Thoma41207132.81