Paper Info
Title
A mathematical model of immune-system-melanoma competition.
Abstract
We present a mathematical model developed to reproduce the immune response entitled with the combined administration of activated OT1 cytotoxic T lymphocytes (CTLs) and Anti-CD137 monoclonal antibodies. The treatment is directed against melanoma in B16 OVA mouse models exposed to a specific immunotherapy strategy. We model two compartments: the injection point compartment where the treatment is administered and the skin compartment where melanoma tumor cells proliferate. To model the migration of OT1 CTLs and antibodies from the injection to the skin compartment, we use delay differential equations (DDEs). The outcomes of the mathematical model are in good agreement with the in vivo results. Moreover, sensitivity analysis of the mathematical model underlines the key role of OT1 CTLs and suggests that a possible reduction of the number of injected antibodies should not affect substantially the treatment efficacy.
Year
DOI
Venue
2012
10.1155/2012/850754
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
Keywords
Field
DocType
immune system
Monoclonal antibody,Immunology,Biology,Compartment (ship),In vivo,Immune system,Melanoma,Cytotoxic T cell,Antibody,Immunotherapy
Journal
Volume
ISSN
Citations 
2012
1748-670X
1
PageRank 
References 
Authors
0.37
2
1
Name
Order
Citations
PageRank
Marzio Pennisi110923.03