Paper Info
Title
Fusion of Positron Emission Tomography (PET) and Gene Array Data: A New Approach for the Correlative Analysis of Molecular Biological and Clinical Data.
Abstract
The combined assessment of data obtained by positron emission tomography (PET) and gene array techniques provide new capabilities for the interpretation of kinetic tracer studies. The correlative analysis of the data helps to detect de- pendencies of the kinetics of radiotracer on gene expression. Furthermore, gene expression may be predicted using regression functions if a significant correlation exists, which raises new aspects regarding the interpretation of dynamic PET examina- tions. The development of new radiopharmaceuticals requires the knowledge of the enhanced expression of genes, especially genes controlling receptors and cell surface proteins. The GenePET program facilitates an interactive approach together with the use of key words to identify possible targets for new radiopharmaceu- ticals.
Year
DOI
Venue
2007
10.1109/TMI.2007.892645
IEEE Trans. Med. Imaging
Keywords
Field
DocType
gene expression,nuclear medicine,gene array,pet,proteins,regression analysis,kinetic theory,molecular biology,gene expression profiling,genetics,kinetics,biochemistry,protein engineering,radiopharmaceuticals,indexing terms,data analysis,cancer,modeling,radio control,molecular biophysics
Kinetic theory,Positron emission tomography,Artificial intelligence,Cell Surface Proteins,Computational biology,Correlative,Computer vision,Medical treatment,Molecular biophysics,Bioinformatics,Mathematics,DNA microarray,Gene expression profiling
Journal
Volume
Issue
ISSN
26
6
0278-0062
Citations 
PageRank 
References 
1
0.36
1
Authors
10
Name
Order
Citations
PageRank
L G Strauss141.35
Leyun Pan241.89
Dirk Koczan3313.16
Sven Klippel410.70
Krzysztof Mikolajczyk521.10
Cyrill Burger641.85
Uwe Haberkorn710.36
Klaus Schonleben810.36
Hans-Jürgen Thiesen9272.86
A Dimitrakopoulou-Strauss1041.69