Name
Title | ||
|---|---|---|
The current functional state of local neuronal circuits controls the magnitude of a BOLD response to incoming stimuli. |
Abstract | ||
|---|---|---|
The purpose of this study was to determine how the history-dependent activation state of neuronal networks controls fMRI signals to incoming stimuli. Simultaneous electrophysiological and blood oxygen level-dependent (BOLD) responses were monitored during stimulation of the perforant pathway with low, high, and again low intensity but, otherwise identical pulse trains. Under three different anesthetics (α-chloralose, medetomidine, isoflurane) consecutive low intensity stimulation trains, set just below the threshold for population spike generation to single pulses, yielded a stable BOLD response, although at different magnitudes. The first high intensity train increased the BOLD response under all anesthetics and generated population spikes, with varying amplitudes and latencies (α-chloralose, metedomidine) or in a regular pattern (isoflurane). Concurrent to the second high intensity train, the BOLD response became minimal, then slowly increasing with subsequent trains (α-chloralose, metedomidine), or immediately rising to a stable level (isoflurane). Second train population spikes became regularized, but at low amplitudes and long latencies that were slowly reversed across trains (α-chloralose, medetomidine); while under isoflurane, amplitude and latencies became stabilized with the second train. In comparison to initial stimulation, the final low intensity stimulation trains failed to produce BOLD responses (α-chloralose, medetomidine), or left the response unchanged (isoflurane), only reaching stable potentiation of population spikes when under isoflurane. Therefore, the fate of BOLD responses depends on whether a new stable functional state of the intrinsic network can be reached after high intensity stimulation. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1016/j.neuroimage.2010.01.070 | NeuroImage |
Keywords | Field | DocType |
neuronal network | Population,Neuroscience,Anesthesia,Cognitive psychology,Psychology,Pulse (signal processing),Stimulus (physiology),Isoflurane,Electrophysiology,Stimulation,Population spike,Medetomidine | Journal |
Volume | Issue | ISSN |
50 | 4 | 1053-8119 |
Citations | PageRank | References |
4 | 0.97 | 2 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Frank Angenstein | 1 | 30 | 5.56 |
| Karla Krautwald | 2 | 9 | 2.22 |
| Henning Scheich | 3 | 147 | 29.04 |