Name
Title | ||
|---|---|---|
Hill kinetics meets P systems: a case study on gene regulatory networks as computing agents in silico and in vivo |
Abstract | ||
|---|---|---|
Modeling and simulation of biological reaction networks is an essential task in systems biology aiming at formalization, understanding, and prediction of processes in living organisms. Currently, a variety of modeling approaches for specific purposes coexists. P systems form such an approach which owing to its algebraic nature opens growing fields of application. Here, emulating the dynamical system behavior based on reaction kinetics is of particular interest to explore network functions. We demonstrate a transformation of Hill kinetics for gene regulatory networks (GRNs) into the P systems framework. Examples address the switching dynamics of GRNs acting as NAND gate and RS flip-flop. An adapted study in vivo experimentally verifies both practicability for computational units and validity of the system model. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1007/978-3-540-77312-2_20 | Workshop on Membrane Computing |
Keywords | Field | DocType |
nand gate,biological reaction network,hill kinetics,system model,systems biology,gene regulatory network,rs flip-flop,p system,p systems framework,reaction kinetics,case study,dynamical system behavior,dynamic system,system biology,system modeling,kinetics | Modeling and simulation,Computer science,Systems biology,NAND gate,Artificial intelligence,Gene regulatory network,Dynamical system,System model,In silico,Distributed computing | Conference |
Volume | ISSN | ISBN |
4860 | 0302-9743 | 3-540-77311-8 |
Citations | PageRank | References |
7 | 0.79 | 10 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Thomas Hinze | 1 | 97 | 12.37 |
| Sikander Hayat | 2 | 81 | 5.84 |
| Thorsten Lenser | 3 | 100 | 7.25 |
| Naoki Matsumaru | 4 | 50 | 7.56 |
| Peter Dittrich | 5 | 103 | 14.01 |