Name
Title | ||
|---|---|---|
MRI-constrained spectral imaging of benzodiazepine modulation of spontaneous neuromagnetic activity in human cortex. |
Abstract | ||
|---|---|---|
Spontaneous electromagnetic brain rhythms have been widely used in human neuropharmacology, but their applicability is complicated by the difficulties to localize their origins in the human cortex. Here, we used a novel multi-modal non-invasive imaging approach to localize lorazepam (30 μg/kg i.v.) modulation of cortical generators of spontaneous brain rhythms. Eight healthy subjects were measured with 306-channel magnetoencephalography (MEG) in a double-blind, randomized, placebo-controlled (saline), crossover design. For anatomically realistic source modeling, wavelet-transformed MEG data were combined with high-resolution MRI to constrain the current locations to the cortical mantle, after which individual data were co-registered to surface-based coordinate system for the calculation of group statistical parametric maps of drug effects. The distributed MRI-constrained MEG source estimates demonstrated decreased alpha (10 Hz) activity in and around the parieto-occipital sulcus and in the calcarine sulcus of the occipital lobe, following from increased GABAA-inhibition by lorazepam. Anatomically constrained spectral imaging displays the cortical loci of drug effects on oscillatory brain activity, providing a novel tool for human pharmacological neuroimaging. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1016/j.neuroimage.2006.12.033 | NeuroImage |
Keywords | Field | DocType |
spectral imaging,wavelet transform,high resolution,crossover design,magnetoencephalography,coordinate system | Cortex (botany),Developmental psychology,Neuroscience,Spectral imaging,Psychology,Brain activity and meditation,Sulcus,Neuroimaging,Occipital lobe,Magnetoencephalography,Calcarine sulcus | Journal |
Volume | Issue | ISSN |
35 | 2 | 1053-8119 |
Citations | PageRank | References |
3 | 0.66 | 6 |
Authors | ||
8 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jyrki Ahveninen | 1 | 89 | 15.15 |
| Fa-Hsuan Lin | 2 | 246 | 24.33 |
| Reetta Kivisaari | 3 | 9 | 1.99 |
| Taina Autti | 4 | 42 | 6.28 |
| Matti Hämäläinen | 5 | 911 | 140.69 |
| Steven Stufflebeam | 6 | 3 | 0.66 |
| John W Belliveau | 7 | 256 | 38.29 |
| S Kähkönen | 8 | 38 | 7.27 |