Name
Title | ||
|---|---|---|
Coryneregnet 2: An Integrative Bioinformatics Approach For Reconstruction And Comparison Of Transcriptional Regulatory Networks In Prokaryotes |
Abstract | ||
|---|---|---|
CoryneRegNet is an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. Initially, it was designed to provide methods for the analysis and visualization of the gene regulatory network of Corynebacterium glutamicum. Now we integrated the genomes and transcriptional interactions of three other corynebacteria, C. diphtheriae, C. efficiens, and C. jeikeium into CoryneRegNet; providing comparative analysis and visualization with GraphVis. We also integrated the high-performance PSSM search tool PoSSuMsearch to detect potential transcription factor binding sites within and across species. As an application, we reconstruct in silico the regulatory network of the iron metabolism regulator DtxR in the four corynebacteria. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.2390/biecoll-jib-2006-24 | JOURNAL OF INTEGRATIVE BIOINFORMATICS |
Keywords | Field | DocType |
comparative analysis,data warehouse,gene regulatory network,transcription factor binding site | Genome,Data mining,Corynebacterium glutamicum,DNA binding site,Computer science,Bioinformatics,Gene regulatory network,Integrative bioinformatics,In silico | Journal |
Volume | Issue | ISSN |
3 | 2 | 1613-4516 |
Citations | PageRank | References |
7 | 0.59 | 6 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jan Baumbach | 1 | 148 | 22.11 |
| Karina Brinkrolf | 2 | 7 | 0.59 |
| Tobias Wittkop | 3 | 95 | 6.10 |
| Andreas Tauch | 4 | 63 | 5.11 |
| Sven Rahmann | 5 | 633 | 59.13 |