Name
Title | ||
|---|---|---|
[18F]FDOPA uptake in the raphe nuclei complex reflects serotonin transporter availability. A combined [18F]FDOPA and [11C]DASB PET study in Parkinson's disease. |
Abstract | ||
|---|---|---|
Brain uptake of [18F]FDOPA, measured with PET, reflects the activity of aromatic amino acid decarboxylase, an enzyme largely expressed in monoaminergic nerve terminals. This enzyme catalyzes a number of decarboxylation reactions including conversion of l-dopa into dopamine and 5-hydroxytryptophan into serotonin. For more than 20years [18F]FDOPA PET has been used to assess dopaminergic nigrostriatal dysfunction in patients with Parkinson's disease (PD). More recently, however, [18F]FDOPA PET has also been employed as a marker of serotoninergic and noradrenergic function in PD patients. In this study, we provide further evidence in support of the view that [18F]FDOPA PET can be used to evaluate the distribution and the function of serotoninergic systems in the brain. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1016/j.neuroimage.2011.09.034 | NeuroImage |
Keywords | Field | DocType |
Positron emission tomography (PET),[18F]FDOPA,[11C]DASB serotonin Parkinson,Monoamine,Extrastriatal | Serotonergic,Neuroscience,Dopaminergic,Serotonin transporter,Developmental psychology,Internal medicine,DASB,Raphe,Psychology,Serotonin transport,Monoaminergic,Raphe nuclei,Endocrinology | Journal |
Volume | Issue | ISSN |
59 | 2 | 1053-8119 |
Citations | PageRank | References |
2 | 0.35 | 2 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Nicola Pavese | 1 | 5 | 2.58 |
| B. S. Simpson | 2 | 2 | 0.35 |
| V. Metta | 3 | 2 | 0.35 |
| Anil Ramlackhansingh | 4 | 46 | 3.00 |
| K. Ray Chaudhuri | 5 | 3 | 0.72 |
| David J. Brooks | 6 | 24 | 7.54 |