Name
Title | ||
|---|---|---|
Analysis of population dynamics in beta-cell destruction lead to identification of novel candidate genes for type 1 diabetes |
Abstract | ||
|---|---|---|
A major difficulty in the genetic study of type 1 diabetes (T1D) is the lack of means to identify candidate disease genes, as the exact disease etiology is still unclear. We have developed a minimal model for T1D where we mathematically formulate the population dynamics for the most critical components in β-cell destruction: macrophages, T lymphocytes, β cells and β-cell autoantigens. System dynamic stability analysis revealed that the disease process for adult individuals is critically regulated by several major gene regulation pathways. Together they provide a comprehensive picture of where the candidate genes most likely lie. We will present our model, our bioinformatics platform to retrieve and update the gene information involved in the pathways, and our candidate gene database. In addition we will present our plan of candidate gene genotyping. Our approach represents the first time understanding the disease dynamics is integrated with the genetic study of a complex disease. |
Year | DOI | Venue |
|---|---|---|
2004 | 10.1109/CSB.2004.1332459 | CSB |
Keywords | Field | DocType |
β-cell autoantigens,t lymphocytes,cellular biophysics,novel candidate genes,diseases,type 1 diabetes,gene regulation pathways,candidate disease genes,genetics,information retrieval,physiological models,gene information update,candidate gene genotyping,system dynamic stability analysis,genetic study,disease process,candidate disease gene,gene information retrieval,complex disease,exact disease etiology,candidate gene database,beta-cell destruction,macrophages,stability,medical diagnostic computing,bioinformatics,disease dynamic,gene information,population dynamics,candidate gene,stability analysis,gene regulation,population dynamic,system dynamics | Population,Major gene,Disease,Genotyping,Gene,Biology,Candidate gene,Bioinformatics,Beta (finance),Genetics,Beta cell | Conference |
ISBN | Citations | PageRank |
0-7695-2194-0 | 0 | 0.34 |
References | Authors | |
0 | 2 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Yizhou Xie | 1 | 0 | 0.68 |
| Xujing Wang | 2 | 90 | 8.54 |