Name
Abstract | ||
|---|---|---|
We present a reaction-diffusion model of [Ca2+] regulation in neuronal dendrites, in the presence of high-affinity indicator and endogenous buffers. We investigate the
applicability of equilibration assumptions for a slow, NMDAR-like source, present an analytical solution to the system in
linear approximation, and discuss a possible scheme for extending this approximation’s applicability. We obtain data on spatial
Ca2+ spread that suggest that dendritic Ca2+ signals of NMDAR origin can be localized to 2–3 μm with no need for differential buffering or spines. Finally, we show that
the difficulties presented by dye saturation may be circumvented by using fluorescence tails as a probe of [Ca2+] peaks.
|
Year | DOI | Venue |
|---|---|---|
1999 | 10.1007/BFb0098159 | IWANN (1) |
Keywords | Field | DocType |
immobile buffers,linear approximation,reaction diffusion,analytic solution | Linear approximation,Discrete mathematics,Chemical physics,Saturation (chemistry),Computer science,Fluorescence,Biological modeling | Conference |
Volume | ISSN | ISBN |
1606 | 0302-9743 | 3-540-66069-0 |
Citations | PageRank | References |
0 | 0.34 | 3 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Miguel Maravall | 1 | 5 | 1.58 |
| Zachary F. Mainen | 2 | 130 | 47.99 |
| Karel Svoboda | 3 | 92 | 10.18 |