Name
Abstract | ||
|---|---|---|
The evolution of positron emission tomography (PET) imaging for small animals has led to the development of dedicated PET scanner designs with high resolution and sensitivity. The animal PET scanner achieves these goals for imaging small animals such as mice and rats. The scanner uses a pixelated Anger-logic detector for discriminating 2 x 2 x 10 mm3 crystals with 19-mm-diameter photomultiplier tubes. With a 19.7-cm ring diameter, the scanner has an axial length of 11.9 cm and operates exclusively in three-dimensional imaging mode, leading to very high sensitivity. Measurements show that the scanner design achieves a spatial resolution of 1.9 mm at the center of the field-of-view. Initially designed with gadolinium orthosilicate but changed to lutetium- yttrium orthosilicate, the scanner now achieves a sensitivity of 3.6% for a point source at the center of the field-of-view with an energy window of 250-665 keV. Iterative image reconstruction, together with accurate data corrections for scatter, random, and attenuation, are incorporated to achieve high-quality images and quantitative data. These results are demonstrated through our contrast recovery measurements as well as sample animal studies. |
Year | DOI | Venue |
|---|---|---|
2005 | 10.1109/TMI.2005.844078 | IEEE Trans. Med. Imaging |
Keywords | Field | DocType |
animal positron emission tomography (pet) imaging,high sensitivity,19 mm,anger detector with gadolinium orthosilicate (gso) or lutetium-yttrium orthosilicate (lyso),luysio,rats,solid scintillation detectors,high resolution,250 to 665 kev,2 mm,contrast recovery measurements,image resolution,11.9 cm,mice,yttrium compounds,19.7 cm,small animal pet camera,lutetium-yttrium orthosilicate,image reconstruction,10 mm,pixelated anger-logic detector,photomultiplier tubes,positron emission tomography,lutetium compounds,iterative image reconstruction,data corrections,imaging performance,medical image processing,detectors,spatial resolution,field of view,photomultipliers,animal studies,crystals,point source,miniaturization | Nuclear medicine,Orthosilicate,Positron emission tomography,Artificial intelligence,Detector,Iterative reconstruction,Computer vision,Optics,Scanner,Attenuation,Image resolution,Photomultiplier,Mathematics | Journal |
Volume | Issue | ISSN |
24 | 7 | 0278-0062 |
Citations | PageRank | References |
3 | 0.83 | 2 |
Authors | ||
7 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Suleman Surti | 1 | 13 | 2.41 |
| Joel S Karp | 2 | 13 | 2.74 |
| Amy E Perkins | 3 | 3 | 1.17 |
| Chris A Cardi | 4 | 3 | 0.83 |
| Margaret E. Daube-witherspoon | 5 | 64 | 19.35 |
| Austin Kuhn | 6 | 3 | 0.83 |
| Gerd Muehllehner | 7 | 3 | 0.83 |