Paper Info
Title
ARTreat Project: three-dimensional numerical simulation of plaque formation and development in the arteries.
Abstract
Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.
Year
DOI
Venue
2012
10.1109/TITB.2011.2168418
IEEE Transactions on Information Technology in Biomedicine
Keywords
Field
DocType
computer simulation,reaction diffusion,blood viscosity,media,partial differential equation,proteins,three dimensional,blood pressure,mathematical model,blood flow,wall shear stress,haemodynamics,algorithms,continuity equation,numerical simulation,image segmentation
Hemodynamics,Artery,Cholesterol,Blood flow,Computer science,Constriction,Lipoprotein,Pathology,Blood vessel,Endothelium
Journal
Volume
Issue
ISSN
16
2
1558-0032
Citations 
PageRank 
References 
11
2.10
1
Authors
10
Name
Order
Citations
PageRank
Nenad Filipovic15931.21
Mirko Rosic2112.43
Irena Tanaskovic3112.10
Zarko Milosevic45610.35
Dalibor Nikolic5227.64
Nebojsa Zdravkovic6215.93
Aleksandar Peulic72410.00
Milos Kojic8175.68
Dimitrios I. Fotiadis9941121.32
Oberdan Parodi105313.16