Paper Info
Title
Comparison of Rule-Based and DTMRI-Derived Fibre Architecture in a Whole Rat Ventricular Computational Model
Abstract
The anisotropic electrical conduction within myocardial tissue due to preferential cardiac myocyte orientation (`fibre orientation) is known to impact strongly in electrical wavefront dynamics, particularly during arrhythmogenesis. Faithful representation of cardiac fibre architecture within computational cardiac models which seek to investigate such phenomena is thus imperative. Drawbacks in derivation of fibre structure from imaging modalities often render rule-based representations based on a priori knowledge preferential. However, the validity of using such rule-based approaches within whole ventricular models remains unclear. Here, we present the development of a generic computational framework to directly compare the fibre architecture predicted by rule-based methods used within whole ventricular models against fibre structure derived from DTMRI data, and assess how relative differences influence propagation dynamics throughout the ventricles. Results demonstrate the close overall match between the methods within the rat ventricles, and highlight regions for potential rule-adaption.
Year
DOI
Venue
2009
10.1007/978-3-642-01932-6_10
FIMH
Keywords
DocType
Volume
rule-based approach,cardiac fibre architecture,fibre structure,computational cardiac model,dtmri-derived fibre architecture,render rule-based representation,preferential cardiac myocyte orientation,whole ventricular model,fibre orientation,fibre architecture,whole rat ventricular computational,rule-based method,cardiac electrophysiology
Conference
5528
ISSN
Citations 
PageRank 
0302-9743
7
1.03
References 
Authors
5
6
Name
Order
Citations
PageRank
Martin J. Bishop13912.93
Patrick Hales281.79
G Plank320133.05
David Gavaghan421330.44
Jürgen Scheider571.03
Vicente Grau617813.55