Title
Automated landmark identification for human cortical surface-based registration.
Abstract
Volume-based registration (VBR) is the predominant method used in human neuroimaging to compensate for individual variability. However, surface-based registration (SBR) techniques have an inherent advantage over VBR because they respect the topology of the convoluted cortical sheet. There is evidence that existing SBR methods indeed confer a registration advantage over affine VBR. Landmark-SBR constrains registration using explicit landmarks to represent corresponding geographical locations on individual and atlas surfaces. The need for manual landmark identification has been an impediment to the widespread adoption of Landmark-SBR. To circumvent this obstacle, we have implemented and evaluated an automated landmark identification (ALI) algorithm for registration to the human PALS-B12 atlas. We compared ALI performance with that from two trained human raters and one expert anatomical rater (ENR). We employed both quantitative and qualitative quality assurance metrics, including a biologically meaningful analysis of hemispheric asymmetry. ALI performed well across all quality assurance tests, indicating that it yields robust and largely accurate results that require only modest manual correction (<10min per subject). ALI largely circumvents human error and bias and enables high throughput analysis of large neuroimaging datasets for inter-subject registration to an atlas.
Year
DOI
Venue
2012
10.1016/j.neuroimage.2011.08.093
NeuroImage
Keywords
Field
DocType
Individual variability,PALS-B12,Registration,Anatomical alignment,Cortex,Automated
Affine transformation,Computer vision,Echo-planar imaging,Psychology,Software,Artificial intelligence,Neuroimaging,Landmark,Variable bitrate,Quality assurance
Journal
Volume
Issue
ISSN
59
3
1053-8119
Citations 
PageRank 
References 
3
0.48
10
Authors
7
Name
Order
Citations
PageRank
Alan Anticevic11338.22
Grega Repovs2755.25
Donna L. Dierker3573.94
John W. Harwell41167.93
Timothy S. Coalson565821.48
Deanna M. Barch6118751.86
David C. Van Essen7238198.61