Name
Title | ||
|---|---|---|
Is optical imaging spectroscopy a viable measurement technique for the investigation of the negative BOLD phenomenon? A concurrent optical imaging spectroscopy and fMRI study at high field (7 T). |
Abstract | ||
|---|---|---|
Traditionally functional magnetic resonance imaging (fMRI) has been used to map activity in the human brain by measuring increases in the Blood Oxygenation Level Dependent (BOLD) signal. Often accompanying positive BOLD fMRI signal changes are sustained negative signal changes. Previous studies investigating the neurovascular coupling mechanisms of the negative BOLD phenomenon have used concurrent 2D-optical imaging spectroscopy (2D-OIS) and electrophysiology (Boorman et al., 2010). These experiments suggested that the negative BOLD signal in response to whisker stimulation was a result of an increase in deoxy-haemoglobin and reduced multi-unit activity in the deep cortical layers. However, Boorman et al. (2010) did not measure the BOLD and haemodynamic response concurrently and so could not quantitatively compare either the spatial maps or the 2D-OIS and fMRI time series directly. Furthermore their study utilised a homogeneous tissue model in which is predominantly sensitive to haemodynamic changes in more superficial layers. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1016/j.neuroimage.2012.03.015 | NeuroImage |
Keywords | Field | DocType |
fMRI,Optical imaging,Haemodynamics,Negative BOLD,Biophysical modelling | Brain mapping,Neuroscience,Functional magnetic resonance imaging,Haemodynamic response,Psychology,Human brain,Somatosensory system,Neuroimaging,Electrophysiology,Magnetic resonance imaging | Journal |
Volume | Issue | ISSN |
61 | 1 | 1053-8119 |
Citations | PageRank | References |
5 | 0.53 | 6 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Aneurin J. Kennerley | 1 | 63 | 4.92 |
| John E. W. Mayhew | 2 | 233 | 322.10 |
| Luke Boorman | 3 | 20 | 4.27 |
| Ying Zheng | 4 | 17 | 3.88 |
| Jason Berwick | 5 | 220 | 79.86 |