Name
Title | ||
|---|---|---|
Effects of NMDA and non-NMDA receptors antagonists on the dynamic behavior of cultured cortical networks |
Abstract | ||
|---|---|---|
Non-conventional electrophysiological techniques allow screening the activity of nerve cells in spontaneous and stimulus-evoked conditions. Activity patterns in cultured networks of cortical neurons from rat embryos were investigated at different days in vitro (DIV), by a multi-site recording technique based on planar microelectrode arrays (MEAs). Transitions in neuronal dynamics of the networks were induced by administering antagonists of NMDA and non-NMDA receptors. Neurochemical effects on synaptic transmission were evaluated analyzing the network activity by using ad hoc developed algorithms. A decrease in excitatory synaptic transmission corresponded to a decrease in spiking and bursting activity with a loss of synchronization. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1016/j.neucom.2005.11.014 | Neurocomputing |
Keywords | Field | DocType |
Neuronal network,Microelectrode array,Excitatory synapse,Chemical stimulation | Bursting,Neurochemical,Neuroscience,Neurotransmission,Pattern recognition,NMDA receptor,Excitatory synapse,Synaptic plasticity,Artificial intelligence,Biological neural network,Mathematics,Electrophysiology | Journal |
Volume | Issue | ISSN |
69 | 16 | 0925-2312 |
Citations | PageRank | References |
2 | 0.49 | 3 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| L. Bonzano | 1 | 20 | 2.32 |
| Marco Bove | 2 | 27 | 4.90 |
| S Martinoia | 3 | 158 | 20.68 |