Name
Abstract | ||
|---|---|---|
A radiation beam passes through normal tissue to reach tumor. The latest devices for the radiotherapy of cancer provide intensity
modulated radiation treatment, or IMRT. This method refines cancer treatment by varying the intensity profile across the face
of a radiation beam. Intensity modulation is usually accomplished by partitioning each beam, distinguished by its angle of
entry, into an array of smaller sized units, called beamlets, assigned different intensities. Planning treatment calls for
an optimization over beamlet intensities to maximize the dose delivered to the targeted tumor while keeping the distribution
of dose throughout the various organs within physician prescribed bounds. The choice of beam angles can be entered into the
optimization as well.
A common method to produce an intensity pattern is to block out different parts of the beam for different amounts of time.
This can be done sliding narrow blocks (leafs) of unit width into the beam from either of two opposing sides to create different
beam shapes called segments. A sequence of segments with their exposure times is superimposed to yield the dose distribution
actually received in the patient. Current two stage treatment is derived in separate steps: optimization over independently
considered beamlet intensities, and generation of a sequence of segments to approximate the planned intensity map. The approximation
degrades the solution, and the separate search for segments adds to planning time. We present a mixed integer programming
alternative employing column generation to optimize dose over segments themselves. Only segments that can be realized with
delivery devices are generated, and adjustments made for the effects of block edges, so that the optimized plans are directly
implementable. Preliminary testing demonstrates gains in both planning efficiency and quality of the plans produced. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1007/s10479-006-0080-1 | Annals OR |
Keywords | Field | DocType |
Dose Distribution,Intensity Modulate Radiation Therapy,Column Generation,Beam Angle,Multileaf Collimator | Mathematical optimization,Intensity modulation,Column generation,Optics,Cancer therapy,Multileaf collimator,Radiation therapy,Beam (structure),Mathematics,Radiation,Radiation beam | Journal |
Volume | Issue | ISSN |
148 | 1 | 0254-5330 |
Citations | PageRank | References |
8 | 1.69 | 3 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Felisa Preciado-Walters | 1 | 25 | 3.51 |
| Mark P. Langer | 2 | 19 | 3.06 |
| Ronald L. Rardin | 3 | 300 | 48.84 |
| Van Thai | 4 | 25 | 3.51 |