Paper Info
Title
Automatic classification of patients with Alzheimer's disease from structural MRI: a comparison of ten methods using the ADNI database.
Abstract
Recently, several high dimensional classification methods have been proposed to automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and elderly controls (CN) based on T1-weighted MRI. However, these methods were assessed on different populations, making it difficult to compare their performance. In this paper, we evaluated the performance of ten approaches (five voxel-based methods, three methods based on cortical thickness and two methods based on the hippocampus) using 509 subjects from the ADNI database. Three classification experiments were performed: CN vs AD, CN vs MCIc (MCI who had converted to AD within 18months, MCI converters — MCIc) and MCIc vs MCInc (MCI who had not converted to AD within 18months, MCI non-converters — MCInc). Data from 81 CN, 67 MCInc, 39 MCIc and 69 AD were used for training and hyperparameters optimization. The remaining independent samples of 81 CN, 67 MCInc, 37 MCIc and 68 AD were used to obtain an unbiased estimate of the performance of the methods. For AD vs CN, whole-brain methods (voxel-based or cortical thickness-based) achieved high accuracies (up to 81% sensitivity and 95% specificity). For the detection of prodromal AD (CN vs MCIc), the sensitivity was substantially lower. For the prediction of conversion, no classifier obtained significantly better results than chance. We also compared the results obtained using the DARTEL registration to that using SPM5 unified segmentation. DARTEL significantly improved six out of 20 classification experiments and led to lower results in only two cases. Overall, the use of feature selection did not improve the performance but substantially increased the computation times.
Year
DOI
Venue
2011
10.1016/j.neuroimage.2010.06.013
NeuroImage
Keywords
Field
DocType
Alzheimer's disease,AD,MCI,Converter,Prodromal,Classification,Magnetic resonance imaging,Support vector machines
Voxel,Feature selection,Support vector machine,Psychology,Database,Cognitive impairment
Journal
Volume
Issue
ISSN
56
2
1053-8119
Citations 
PageRank 
References 
228
8.57
32
Authors
10
Search Limit
100228
Name
Order
Citations
PageRank
Rémi Cuingnet141519.36
Gerardin Emilie228910.72
Tessieras Jérôme32288.57
Guillaume Auzias429916.66
Stéphane Lehéricy546726.36
Marie-Odile Habert625512.58
Marie Chupin740222.10
Habib Benali883768.94
Olivier Colliot974349.59
null null106391656.33