Name
Abstract | ||
|---|---|---|
Summary form only given. The recent revelation that the human genome contains only ∼30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA-300 bp to 1,000 bp in length-that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by simple sequence inspection. One of the outstanding issues in the post-genome era is whether there is a "cis-regulatory code" that links primary DNA sequence with gene expression patterns. We have used a combination of bioinformatics methods and functional assays to determine whether coordinately regulated genes share a common "grammar". |
Year | DOI | Venue |
|---|---|---|
2002 | 10.1109/CSB.2002.1039323 | CSB |
Keywords | Field | DocType |
human genome,enhancers,genetics,microorganisms,cis-regulatory dnas,organismal diversity,decoding noncoding regulatory dnas,biology computing,molecular biophysics,noncoding regulatory dna decoding,gene regulation,cis-regulatory code,functional assays,metazoan genomes,dna,bioinformatics methods,embryo,inspection,genomics,sequences,dna sequence,protein engineering,decoding,gene expression,bioinformatics | Genome,Conserved non-coding sequence,Gene,Biology,Genomics,Regulation of gene expression,DNA sequencing,Human genome,Bioinformatics,Regulatory sequence | Conference |
ISBN | Citations | PageRank |
0-7695-1653-X | 3 | 0.41 |
References | Authors | |
0 | 10 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Michele Markstein | 1 | 3 | 0.41 |
| Angela Stathopoulos | 2 | 3 | 0.41 |
| Vicky Markstein | 3 | 3 | 0.41 |
| Peter Markstein | 4 | 70 | 8.47 |
| Naoe Harafuji | 5 | 3 | 0.41 |
| Dave Keys | 6 | 3 | 0.41 |
| Byung-in Lee | 7 | 3 | 0.41 |
| Paul Richardson | 8 | 11 | 0.99 |
| Dan Rokshar | 9 | 3 | 0.41 |
| Mike Levine | 10 | 10 | 3.04 |