Name
Abstract | ||
|---|---|---|
Left ventricular hypertrophy induces remodeling of various ion channels and prolongs depolarization of the ventricles. We modified a model of electrical activity of rat ventricular cell by incorporating available experimental data. Hypertrophy was modeled by incorporating experimental data of changes in sodium (INa), hyperpolarizing (If), outward transient potassium (Ito) and T-type calcium currents channel kinetics (ICaT), cell size and Ca2+ handling. In 1D simulations, a continuous increase in action potential duration (APD) and corresponding decrease in conduction velocity (CV) with subsequent beats was observed, resulting in conduction block at low values of stimulus intervals (SI), for which the simulated action potential (AP) restitution of the cell models has negative slope. |
Year | DOI | Venue |
|---|---|---|
2005 | 10.1007/11494621_16 | FIMH |
Keywords | Field | DocType |
conduction block,cell size,conduction velocity,action potential duration,cell model,available experimental data,rat ventricular cell,rat virtual left ventricular,experimental data,ventricular hypertrophy,simulated action potential,potassium,kinetics,action potential,ion channel | Ventricular action potential,Left ventricular hypertrophy,Muscle hypertrophy,Nerve conduction velocity,Calcium,Internal medicine,Cardiology,Chemistry,Depolarization,Ion channel,Cardiac transient outward potassium current | Conference |
Volume | ISSN | ISBN |
3504 | 0302-9743 | 3-540-26161-3 |
Citations | PageRank | References |
0 | 0.34 | 1 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| S. Kharche | 1 | 14 | 1.55 |
| Henggui Zhang | 2 | 105 | 51.88 |
| R. C. Clayton | 3 | 0 | 0.34 |
| Arun V. Holden | 4 | 52 | 20.71 |