Name
Title | ||
|---|---|---|
Quantifying the Trade-off Between IMRT Treatment Plan Quality and Delivery Efficiency Using Direct Aperture Optimization |
Abstract | ||
|---|---|---|
Beam-on time is an important measure of the delivery efficiency in intensity-modulated radiation therapy (IMRT). Traditionally, minimizing beam-on time has been postponed until the leaf sequencing stage, where the treatment plan quality is already determined and fixed. However, there is a trade-off between the beam-on time and the treatment plan quality. The aim of this study is to incorporate the beam-on time into the treatment plan optimization stage using a direct aperture optimization approach that allows for explicitly quantifying the trade-off. The proposed approach can provide clinicians with valuable information for each patient case so that they can design clinically attractive yet efficient treatment plans. Using the special structure of the problem, we propose an exact solution approach that sequentially characterizes segments of the Pareto-efficient frontier. In addition, an approximate solution technique that is applicable to more classes of evaluation criteria is developed. Our approximate technique is tested on clinical cancer cases, and its performance is compared with the general approximation techniques that are available for convex bicriteria optimization problems. The results of our experiments validate that our approach can achieve a more accurate representation of the Pareto-efficient frontier with less computational effort. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1287/ijoc.1110.0474 | INFORMS Journal on Computing |
Keywords | Field | DocType |
efficient treatment plan,approximate solution technique,treatment plan optimization stage,exact solution approach,treatment plan quality,direct aperture optimization,direct aperture optimization approach,delivery efficiency,pareto-efficient frontier,imrt treatment plan quality,beam-on time,convex bicriteria optimization problem | Aperture,Mathematical optimization,Regular polygon,Approximate solution,Bicriteria optimization,Intensity-modulated radiation therapy,Mathematics | Journal |
Volume | Issue | ISSN |
24 | 4 | 1091-9856 |
Citations | PageRank | References |
1 | 0.37 | 7 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Ehsan Salari | 1 | 1 | 0.71 |
| H. Edwin Romeijn | 2 | 769 | 83.88 |