Title
Persistence Results for Chemical Reaction Networks with Time-Dependent Kinetics and No Global Conservation Laws
Abstract
New checkable criteria for persistence of chemical reaction networks are proposed, which extend and complement existing ones. The new results allow the consideration of reaction rates which are time-varying, thus incorporating the effects of external signals, and also relax the assumption of existence of global conservation laws, thus allowing for inflows ( production) and outflows (degradation). For time-invariant networks, parameter-dependent conditions for persistence of certain classes of networks are provided. As an illustration, two networks arising in the systems biology literature are analyzed, namely a hypoxia network and an apoptosis network.
Year
DOI
Venue
2011
10.1137/090779401
SIAM JOURNAL ON APPLIED MATHEMATICS
Keywords
Field
DocType
chemical reaction networks,persistence,Petri nets
Mathematical optimization,Petri net,Persistence (computer science),Systems biology,Reaction rate,Chemical reaction,Kinetics,Mathematics,Conservation law
Journal
Volume
Issue
ISSN
71
1
0036-1399
Citations 
PageRank 
References 
9
1.05
5
Authors
3
Name
Order
Citations
PageRank
David Angeli11264153.03
patrick de leenheer214735.83
Eduardo D. Sontag33134781.88