Title
Hidden Markov models and optimized sequence alignments
Abstract
We present a formulation of the Needleman–Wunsch type algorithm for sequence alignment in which the mutation matrix is allowed to vary under the control of a hidden Markov process. The fully trainable model is applied to two problems in bioinformatics: the recognition of related gene/protein names and the alignment and scoring of homologous proteins.
Year
DOI
Venue
2003
10.1016/S1476-9271(02)00096-8
Computational Biology and Chemistry
Keywords
DocType
Volume
Algorithm,Optimization,Gene synonyms,Sequence alignment
Journal
27
Issue
ISSN
Citations 
1
1476-9271
2
PageRank 
References 
Authors
0.44
2
3
Name
Order
Citations
PageRank
Lawrence H. Smith119614.48
Lana Yeganova2899.92
W. John Wilbur343045.66