Paper Info
Title
MeTaDoR: a comprehensive resource for membrane targeting domains and their host proteins.
Abstract
Motivation: Protein-lipid interactions play a central role in cellular signaling and membrane trafficking and at the core of these interactions are domains specialized in lipid binding and membrane targeting. Considering the importance of these domains, we have created MeTaDoR, a comprehensive resource dedicated to membrane targeting domains (MTDs). Result: MeTaDoR begins with a brief introduction about all the important MTDs including their subcellular localization and structural features. Sequences of all known MTDs are then provided in two formats: standard Prosite format and a parsed tab-delimited format that provides a manually curated classification into binding or non-binding. Structures of all MTDs and host proteins known so far are provided with links to PDB and Pfam databases. Membrane-binding orientation of these proteins, whether experimentally determined or proposed, is also provided with links to the appropriate literature. To facilitate molecular dynamics studies of these proteins, the force-field parameters for many non-standard lipids that commonly interact with these proteins are also provided. Finally, an online server for predicting membrane-binding proteins and a search function with various search fields are included. The resource is publicly available and will be updated on a regular basis. Availability: http://proteomics.bioengr.uic.edu/metador Contact: huilu@uic.edu.
Year
DOI
Venue
2007
10.1093/bioinformatics/btm395
BIOINFORMATICS
Keywords
Field
DocType
force field,binding protein,molecular dynamic
Computer science,Cell signaling,Bioinformatics,Protein Data Bank (RCSB PDB),PROSITE,Subcellular localization
Journal
Volume
Issue
ISSN
23
22
1367-4803
Citations 
PageRank 
References 
3
0.50
11
Authors
5
Name
Order
Citations
PageRank
Nitin Bhardwaj113410.05
Robert V Stahelin230.50
Guijun Zhao330.50
Wonhwa Cho430.50
Hui Lu5496.27