Name
Title | ||
|---|---|---|
Interaction of COMT valmet and externalizing behavior: Relation to prefrontal brain activity and behavioral performance. |
Abstract | ||
|---|---|---|
A promising approach in neuroimaging studies aimed at understanding effects of single genetic variants on behavior is the study of gene–trait interactions. Variation in the catechol-O-methyl-transferase gene (COMT) is associated with the regulation of dopamine levels in the prefrontal cortex and with cognitive functioning. Given the involvement of dopaminergic neurotransmission in externalizing behavior, a trait characterized by impulsivity and aggression, especially in men, externalizing (as a trait) may index a set of genetic, environmental, and neural characteristics pertinent to understanding phenotypic effects of genetic variation in the COMT gene. In the current study, we used a gene–trait approach to investigate effects of the COMT val158met polymorphism and externalizing on brain activity during moments involving low or high demands on cognitive control. In 104 male participants, interference-related activation depended conjointly on externalizing and val158met: stronger activation in the dorsal anterior cingulate and lateral prefrontal cortex was found for val/val individuals with high trait externalizing while stronger activation in cingulate motor areas and sensorimotor precuneus was found for met/met individuals with low externalizing. Our results suggest that the val/val genotype, coupled with high levels of trait externalizing, lowers the efficiency of stimulus conflict resolution, whereas the met/met genotype, coupled with low levels of externalizing, lowers the efficiency of response selection. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1016/j.neuroimage.2012.01.097 | NeuroImage |
Keywords | DocType | Volume |
COMT,Externalizing,fMRI,Genetics,Inhibitory control,MSIT | Journal | 60 |
Issue | ISSN | Citations |
4 | 1053-8119 | 0 |
PageRank | References | Authors |
0.34 | 0 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Zarrar Shehzad | 1 | 80 | 5.20 |
| Colin G. DeYoung | 2 | 26 | 3.22 |
| Yoona Kang | 3 | 3 | 0.79 |
| Elena L Grigorenko | 4 | 0 | 0.34 |
| Jeremy R. Gray | 5 | 51 | 6.34 |