Paper Info
Title
Quantitative modeling of neuronal dynamics in C. elegans
Abstract
We present a mathematical model to quantitatively describe the neuronal dynamics in Caenorhabditis elegans. Since calcium imaging is a popular technique to visualize the neuronal activity in C. elegans, the model includes the variable of the fluorescence intensity in addition to the membrane potential and the intracellular calcium concentration. The fluorescence intensity is a quantity which is comparable with the experimental data. The parameters in the model are determined to reproduce the neurophysiological experimental data. Our model exhibits good agreement with the data. We apply the model to a neural circuit for chemotaxis and find that the neuronal activity measured by the fluorescence intensity shows quantitatively different behavior from that measured by the membrane potential in some neurons. The difference is discussed from the viewpoint of neuronal mechanisms.
Year
DOI
Venue
2010
10.1007/978-3-642-17537-4_3
ICONIP (1)
Keywords
DocType
Volume
neuronal dynamic,c. elegans,mathematical model,caenorhabditis elegans,membrane potential,neurophysiological experimental data,neuronal activity,experimental data,fluorescence intensity,neuronal mechanism,quantitative modeling
Conference
6443
ISSN
ISBN
Citations 
0302-9743
3-642-17536-8
3
PageRank 
References 
Authors
0.91
0
2
Name
Order
Citations
PageRank
Masahiro Kuramochi130.91
Yuishi Iwasaki231.25