Name
Abstract | ||
|---|---|---|
Many interacting biomolecular components in cells form different positive or negative feedback loops. When biological signals
transduce through cascades consisting of various loops they will be affected or even distorted. Especially, how to process
various signals buried in various intrinsic and extrinsic noises is an important issue. This paper analyzes how the response
time influences noise filtering ability and how to enhance the ability by coupling different feedback loops. A parameter to
measure the response time of the signal transduction, i.e., τ
0.9, and its relationship between the response time and noise filtering will be discussed. The authors show clearly that the
longer the response time is, the better the ability to filter noises will be. Therefore, to enhance the ability to filter
noises, the authors can prolong the response time by coupling different positive or negative feedback loops. The results provide
a possible approach to enhance the ability to filter noises in larger biomolecular networks. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1007/s11424-010-0209-9 | J. Systems Science & Complexity |
Keywords | Field | DocType |
response time,filtering noises,coupled feedback,signal cycle.,negative feedback,signal transduction,feedback loop | Coupling,Control theory,Negative feedback,Response time,Filter (signal processing),Signal transduction,Mathematics | Journal |
Volume | Issue | ISSN |
23 | 5 | 15597067 |
Citations | PageRank | References |
0 | 0.34 | 4 |
Authors | ||
9 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Dengyu Liu | 1 | 37 | 2.76 |
| liu | 2 | 0 | 0.34 |
| Zengrong Liu | 3 | 222 | 32.89 |
| Luonan Chen | 4 | 1485 | 145.71 |
| Luonan Chen | 5 | 1485 | 145.71 |
| Luonan Chen | 6 | 1485 | 145.71 |
| Ruiqi Wang | 7 | 64 | 15.44 |
| Ruiqi Wang | 8 | 64 | 15.44 |
| Ruiqi Wang | 9 | 64 | 15.44 |