Title
Model-guided respiratory organ motion prediction of the liver from 2D ultrasound.
Abstract
With the availability of new and more accurate tumour treatment modalities such as high-intensity focused ultrasound or proton therapy, accurate target location prediction has become a key issue. Various approaches for diverse application scenarios have been proposed over the last decade. Whereas external surrogate markers such as a breathing belt work to some extent, knowledge about the internal motion of the organs inherently provides more accurate results. In this paper, we combine a population-based statistical motion model and information from 2d ultrasound sequences in order to predict the respiratory motion of the right liver lobe. For this, the motion model is fitted to a 3d exhalation breath-hold scan of the liver acquired before prediction. Anatomical landmarks tracked in the ultrasound images together with the model are then used to reconstruct the complete organ position over time. The prediction is both spatial and temporal, can be computed in real-time and is evaluated on ground truth over long time scales (5.5min). The method is quantitatively validated on eight volunteers where the ultrasound images are synchronously acquired with 4D-MRI, which provides ground-truth motion. With an average spatial prediction accuracy of 2.4mm, we can predict tumour locations within clinically acceptable margins.
Year
DOI
Venue
2014
10.1016/j.media.2014.03.006
Medical Image Analysis
Keywords
Field
DocType
Respiratory motion compensation,Statistical motion model,Spatio-temporal prediction,4D-MRI,Ultrasound
Population,Computer vision,Proton therapy,Pattern recognition,Organ Motion,Ground truth,Artificial intelligence,Breathing,Location prediction,Mathematics,Ultrasound,Focused ultrasound
Journal
Volume
Issue
ISSN
18
5
1361-8415
Citations 
PageRank 
References 
9
0.65
17
Authors
9