Paper Info
Title
Modeling synaptic transmission and quantifying information transfer in the granular layer of the cerebellum
Abstract
Neurons communicate through spikes; their arrangement in different sequences generates the neural code. Spikes are transmitted between neurons via synapses; the mechanism underlying synaptic transmission involves numerous processes including neurotransmitter release and diffusion, postsynaptic receptor activation, and intrinsic electroresponsiveness. Based on available experimental data and theoretical considerations, we have developed a realistic model predicting the dynamics of neurotransmission at the mossy fiber – granule cell synapse of the cerebellum. The model permits systematic investigation of the multiple mechanisms regulating synaptic transmission and provides predictions on the role of the numerous factors driving synaptic plasticity. The model is also employed to quantify information transfer at the mossy fiber – granule cell synaptic relay. This work was funded in part by the EU SpikeForce project (IST-2001-35271 www.spikeforce.org).
Year
DOI
Venue
2005
10.1007/11494669_14
IWANN
Keywords
Field
DocType
realistic model,synaptic transmission,granule cell synapse,numerous process,numerous factor,granule cell,granular layer,available experimental data,eu spikeforce project,quantifying information transfer,mossy fiber,synaptic plasticity,information transfer,neural code
Neuroscience,Synapse,Neurotransmission,Computer science,Neurotransmitter receptor,Granule cell,Synaptic plasticity,Artificial intelligence,AMPA receptor,Cerebellum,Distributed computing,Neurotransmitter
Conference
Volume
ISSN
ISBN
3512
0302-9743
3-540-26208-3
Citations 
PageRank 
References 
4
0.53
5
Authors
5
Name
Order
Citations
PageRank
Egidio D'Angelo15712.77
Thierry Nieus2253.56
Michele Bezzi320127.07
Angelo Arleo419021.48
Olivier J. M. D. Coenen514714.96