Name
Title | ||
|---|---|---|
Performance evaluation of the time-delayed dynamic Bayesian network approach to inferring gene regulatory networks from time series microarray data |
Abstract | ||
|---|---|---|
Inferring gene regulatory networks (GRNs) is a challenging inverse problem. Most existing approaches have understandably low accuracy because of the intrinsic complexity of a biology system and a limited amount of available data. Dynamic Bayesian Network (DBN) is one of the widely used approaches to identify the signals and interactions within gene regulatory pathways of cells. It is well-suited for characterizing time series gene expression data. However, the impacts of network topology, properties of the time series gene expression data, and the number of time points on the inference accuracy of DBN are still unknown or have not been fully investigated. In this paper, the performance of DBN is evaluated using both in-silico yeast data and three growth phases of Yeast Saccharomyces cerevisiae cell cycle data with different time points in terms of precision and recall. The inferred GRNs were compared with the actual GRNs obtained from SGD (The Saccharomyces Genome Database) in terms of precision and recall. This work may provide insight and guideline for the development and improvement of GRN inference methods. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1145/1854776.1854859 | BCB |
Keywords | Field | DocType |
gene regulatory pathway,different time point,time series gene expression,cerevisiae cell cycle data,regulatory network,inferring gene,in-silico yeast data,available data,time point,time-delayed dynamic bayesian network,performance evaluation,time series microarray data,actual grns,grn inference method,dynamic bayesian network,network topology,inverse problem,microarray data,gene regulatory networks,gene regulatory network,dynamic bayesian networks,cell cycle,time series | Data mining,Computer science,Microarray analysis techniques,Artificial intelligence,Inverse problem,Genome database,Inference,Precision and recall,Network topology,Bioinformatics,Gene regulatory network,Machine learning,Dynamic Bayesian network | Conference |
Citations | PageRank | References |
0 | 0.34 | 9 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Haoni Li | 1 | 4 | 1.13 |
| Peng Li | 2 | 0 | 0.34 |
| Chaoyang Zhang | 3 | 230 | 22.23 |
| Nan Wang | 4 | 0 | 0.34 |
| Ping Gong | 5 | 0 | 0.34 |
| Edward Perkins | 6 | 0 | 0.34 |