Paper Info
Title
Mathematical model of wall shear stress-dependent vasomotor response based on physiological mechanisms.
Abstract
Flow-mediated dilation (FMD) is the most commonly used noninvasive method for the assessment of vascular endothelial function; this assessment uses the magnitude of vasodilation according to reactive hyperemia. The physiological mechanism of vasodilation has been well studied; it was recently hypothesized that endothelial function can reversibly be estimated by computational analysis. This leads to more reliable information about cardiovascular risk factors. In this study, we first developed a mathematical model of vasodilation involving both intra- and inter-cellular pathways, which is constructed by integrating small-scale models based on known physiological mechanisms. We evaluated the proposed model with respect to several aspects: reproducibility of the FMD response; analysis of the relationship between FMD and endothelial function; and analysis of underlying mechanisms of low flow-mediated constriction. We confirmed that the simulated results corresponded well with those observed physiologically. Therefore, the results of the present study show that the proposed model has sufficient capability to quantitatively analyze FMD.
Year
DOI
Venue
2014
10.1016/j.compbiomed.2013.11.018
Comp. in Bio. and Med.
Keywords
DocType
Volume
Low flow-mediated constriction,FMD,wall shear stress-dependent vasomotor,Multiscale modeling,endothelial function,Mathematical model,mathematical model,vascular endothelial function,Wall shear stress,flow-mediated dilation,small-scale model,fmd response,physiological mechanism,Vasomotor response,computational analysis,present study show
Journal
45
ISSN
Citations 
PageRank 
1879-0534
0
0.34
References 
Authors
1
2
Name
Order
Citations
PageRank
Yoichi Yamazaki16510.95
Y Kamiyama2125.61