Name
Abstract | ||
|---|---|---|
N-glycosylation is a common protein modification process, which affects a number of properties of proteins. Little is known about the distribution of N-glycosylation sequons, for example, the distance between glycosylated sites and their position in the protein primary sequence. Using a large set of experimentally confirmed eukaryotic N-glycoproteins we analyzed the relative position and distribution of sequons. N-Glycosylation probability was found to be lower in the termini of protein sequences compared to the mid region. N-glycosylated sequons were found much farther from C terminus compared to the N-terminus of the protein sequence and this effect was more pronounced for NXS sequons. The distribution of sequons, modeled based on balls-in-boxes classical occupancy, showed a near-maximum probability. Considerable proportion of sequons was found within a distance of ten amino acids, indicating that the steric hindrance was not a key factor in protein N-glycosylation. Interestingly, the distribution of all sequons present in N-glycoproteins showed a pattern very similar to that of glycosylated sequons. The results indicate that protein N-glycosylation chiefly follows a random design. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1016/j.compbiolchem.2011.01.002 | Computational Biology and Chemistry |
Keywords | Field | DocType |
Distribution,N-glycoprotein,Probability,Randomness,Sequon | Protein sequencing,Biology,Amino acid,Biochemistry,Protein modification process,Steric effects,N-linked glycosylation,Bioinformatics,Genetics,C-terminus,Sequon | Journal |
Volume | Issue | ISSN |
35 | 2 | 1476-9271 |
Citations | PageRank | References |
0 | 0.34 | 1 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| R. Shyama Prasad Rao | 1 | 1 | 1.04 |
| Ole Thomsen Buus | 2 | 1 | 1.04 |
| Bernd Wollenweber | 3 | 20 | 1.08 |