Name
Abstract | ||
|---|---|---|
Detailed comparison and analysis of the output of DNA gene expression arrays from multiple samples require global normalization of the measured individual gene intensities from the different hybridizations. This is needed for accounting for variations in array preparation and sample hybridization conditions.Here, we present a simple, robust and accurate procedure for the global normalization of datasets generated with single-channel DNA arrays based on principal component analysis. The procedure makes minimal assumptions about the data and performs well in cases where other standard procedures produced biased estimates. It is also insensitive to data transformation, filtering (thresholding) and pre-screening. |
Year | DOI | Venue |
|---|---|---|
2004 | 10.1093/bioinformatics/bth170 | Bioinformatics |
Keywords | Field | DocType |
standard procedure,single-channel dna array data,detailed comparison,global normalization,data transformation,individual gene intensity,accurate procedure,single-channel dna,array preparation,dna gene expression array,principal component analysis,dna array,principal component,gene expression | Normalization (statistics),Computer science,Filter (signal processing),Gustatory system,Communication channel,Thresholding,Bioinformatics,DNA microarray,Principal component analysis | Journal |
Volume | Issue | ISSN |
20 | 11 | 1367-4803 |
Citations | PageRank | References |
6 | 1.25 | 5 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Radka Stoyanova | 1 | 52 | 6.23 |
| Troy D. Querec | 2 | 7 | 2.30 |
| Truman R. Brown | 3 | 92 | 10.77 |
| Christos Patriotis | 4 | 9 | 2.68 |