Title
Spatial relationship between neuronal activity and BOLD functional MRI.
Abstract
Despite the ubiquitous use of functional magnetic resonance imaging (fMRI), the extent to which the magnitude and spatial scale of the fMRI signal correlates with neuronal activity is poorly understood. In this study, we directly compared single and multiunit neuronal activity with blood oxygenation level-dependent (BOLD) fMRI responses across a large area of the cat area 18. Our data suggest that at the scale of several millimeters, the BOLD contrast correlates linearly with the underlying neuronal activity. At the level of individual electrode recording sites, however, the correlation between the two signals varied substantially. We conclude from our study that T2*-based positive BOLD signals are a robust predictor for neuronal activity only at supra-millimeter spatial scales.
Year
DOI
Venue
2004
10.1016/j.neuroimage.2003.10.018
NeuroImage
Keywords
DocType
Volume
BOLD,Neuronal activity,fMRI
Journal
21
Issue
ISSN
Citations 
3
1053-8119
24
PageRank 
References 
Authors
7.95
0
6
Name
Order
Citations
PageRank
Dae-Shik Kim18722.31
Itamar Ronen26512.11
Cheryl Olman311817.39
Seong-Gi Kim4247.95
K. Ugurbil512615.68
Louis J Toth6247.95