Name
Title | ||
|---|---|---|
A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation. |
Abstract | ||
|---|---|---|
There is a large body of evidence that serotonin [5-hydroxytryptamine (5-HT)] plays an important role in the transmission and regulation of pain. Here we used positron emission tomography (PET) to study the relationship between baseline 5-HT2A binding in the brain and responses to noxious heat stimulation in a group of young healthy volunteers. Twenty-one healthy subjects underwent PET scanning with the 5-HT2A antagonist, [18F]altanserin. In addition, participants underwent a battery of pain tests using noxious heat stimulation to assess pain threshold, pain tolerance and response to short-lasting phasic and long-lasting (7-minute) tonic painful stimulation. Significant positive correlations were found between tonic pain ratings and [18F]altanserin binding in orbitofrontal (r=0.66; p=0.005), medial inferior frontal (r=0.60; p=0.014), primary sensory–motor (r=0.61; p=0.012) and posterior cingulate (r=0.63; p=0.009) cortices. In contrast, measures of regional [18F]altanserin binding did not correlate with pain threshold, pain tolerance, or suprathreshold phasic pain responses. These data suggest that cortical 5-HT2A receptor availability co-varies with responses to tonic pain. The correlation between [18F]altanserin binding in prefrontal cortex and tonic pain suggests a possible role of this brain region in the modulation and/or cognitive-evaluative appreciation of pain. |
Year | DOI | Venue |
|---|---|---|
2009 | 10.1016/j.neuroimage.2008.10.011 | NeuroImage |
Keywords | Field | DocType |
receptor binding,pain threshold | Tonic (music),Threshold of pain,Internal medicine,Prefrontal cortex,Anesthesia,Psychology,Pain tolerance,Human brain,Altanserin,Posterior cingulate,Endocrinology,Stimulation | Journal |
Volume | Issue | ISSN |
44 | 3 | 1053-8119 |
Citations | PageRank | References |
2 | 0.51 | 2 |
Authors | ||
7 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| R Kupers | 1 | 43 | 5.47 |
| Vibe G Frokjaer | 2 | 14 | 5.32 |
| Arne Naert | 3 | 2 | 0.84 |
| Rune Christensen | 4 | 2 | 0.51 |
| Esben Budtz-Joergensen | 5 | 4 | 1.27 |
| Henrik Kehlet | 6 | 2 | 0.84 |
| Gitte M. Knudsen | 7 | 89 | 17.15 |