Paper Info
Title
Simulation of the release and diffusion of neurotransmitters in neuronal synapses: Analysis and modelling
Abstract
Chemical synaptic transmisssion involves the release of a neurotransmitter that diffuses in the extracellular space and interacts with specific receptors located on the postsynaptic membrane. Computer simulation approaches provide fundamental tools for exploring various aspects of the synaptic transmission under different conditions. In particular, Monte Carlo methods can track the stochastic movements of neurotransmitter molecules and their interactions with other discrete molecules, the receptors. We have developed synaptic models that had a simple geometry as far as shape is concerned, but had a variable set of parameters that specified the dimensions of the structures involved in the synaptic junction. We have analyzed simulations based on these idealized models of excitatory synapses where AMPA receptors are present and the neurotransmitter involved is glutamate.
Year
DOI
Venue
2012
10.1109/HPCSim.2012.6266997
High Performance Computing and Simulation
Keywords
Field
DocType
Monte Carlo methods,biochemistry,biodiffusion,biomembrane transport,digital simulation,medical computing,molecular biophysics,neurophysiology,physiological models,proteins,stochastic processes,AMPA receptors,Monte Carlo methods,chemical synaptic transmission,excitatory synapses,glutamate,neuronal synapses,neurotransmitter diffusion,neurotransmitter release,postsynaptic membrane,stochastic movements,AMPA,Monte Carlo,glutamate,simulation,synapse
Synapse,Neuroscience,Neurotransmission,Neurophysiology,Excitatory postsynaptic potential,Receptor,AMPA receptor,Glutamate receptor,Neurotransmitter,Physics
Conference
ISBN
Citations 
PageRank 
978-1-4673-2359-8
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Elena Gómez Barroso100.34
José María Peña Sánchez2194.79
Ángel Merchán-Pérez332.12