Name
Title | ||
|---|---|---|
Spontaneous coordinated activity in cultured networks: Analysis of multiple ignition sites, primary circuits, and burst phase delay distributions. |
Abstract | ||
|---|---|---|
All higher order central nervous systems exhibit spontaneous neural activity, though the purpose and mechanistic origin of
such activity remains poorly understood. We quantitatively analyzed the ignition and spread of collective spontaneous electrophysiological
activity in networks of cultured cortical neurons growing on microelectrode arrays. Leader neurons, which form a mono-synaptically
connected primary circuit, and initiate a majority of network bursts were found to be a small subset of recorded neurons.
Leader/follower firing delay times formed temporally stable positively skewed distributions. Blocking inhibitory synapses
usually resulted in shorter delay times with reduced variance. These distributions are characterizations of general aspects
of internal network dynamics and provide estimates of pair-wise synaptic distances. The resulting analysis produced specific
quantitative constraints and insights into the activation patterns of collective neuronal activity in self-organized cortical
networks, which may prove useful for models emulating spontaneously active systems. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1007/s10827-007-0059-1 | Journal of Computational Neuroscience |
Keywords | Field | DocType |
Burst leaders,Burst patterns,Spontaneous activity,Primary cultures,Hierarchical connectivity,Population responses | Ignition system,Synapse,Neuroscience,Premovement neuronal activity,Network dynamics,Burst phase,Control theory,Simulation,Inhibitory postsynaptic potential,Electronic circuit,Mathematics,Electrophysiology | Journal |
Volume | Issue | ISSN |
24 | 3 | 1573-6873 |
Citations | PageRank | References |
8 | 1.05 | 2 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Michael I. Ham | 1 | 22 | 2.39 |
| Luís M. A. Bettencourt | 2 | 94 | 9.47 |
| Floyd D. McDaniel | 3 | 8 | 1.05 |
| Guenter W. Gross | 4 | 12 | 5.31 |