Name
Title | ||
|---|---|---|
Contributions of dynamic venous blood volume versus oxygenation level changes to BOLD fMRI. |
Abstract | ||
|---|---|---|
Blood-oxygenation-level-dependent (BOLD) fMRI has contributions from venous oxygenation and venous cerebral blood volume (CBV) changes. To examine the relative contribution of venous CBV change (ΔCBVv) to BOLD fMRI, BOLD and arterial CBV changes (ΔCBVa) to a 40-s forepaw stimulation in six α-chloralose anesthetized rats were measured using a magnetization transfer-varied fMRI technique, while total CBV change (ΔCBVt) was measured with injection of iron oxide nanoparticles. ΔCBVv was obtained by subtracting ΔCBVa from ΔCBVt. We observed a fast ΔCBVa response with a time constant of 2.9±2.3s and a slower ΔCBVv response with a time constant of 13.5±5.7s and an onset delay of 6.1±3.3s. These results are consistent with earlier studies under different anesthesia and stimulus, supporting that fast CBVa and slow CBVv responses are generalizable. Assuming the observed post-stimulus BOLD undershoot is at least partly explained by the ΔCBVv contribution, the relative contribution of the ΔCBVv- and oxygenation-change-related components to the BOLD response was estimated. The relative ΔCBVv contribution increases with time during stimulation; whereby it is <0.14 during initial 10s and reaches a maximum possible value of ~0.45 relative to the oxygenation contribution during the 30–40s period after stimulus onset. Our data indicates that the contribution of venous oxygenation change to BOLD fMRI is dominant for short stimulations. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1016/j.neuroimage.2012.02.052 | NeuroImage |
Keywords | Field | DocType |
CBV,BOLD,BOLD undershoot,Cerebral arterial blood volume,Cerebral venous blood volume,Venous oxygenation level | Cerebral blood volume,Anesthesia,Cerebrovascular Circulation,Psychology,Cognitive psychology,Oxygenation,Blood volume,Nuclear magnetic resonance,Venous blood | Journal |
Volume | Issue | ISSN |
60 | 4 | 1053-8119 |
Citations | PageRank | References |
6 | 0.50 | 5 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Xiaopeng Zong | 1 | 28 | 3.42 |
| Tae Kim | 2 | 32 | 2.42 |
| Seong-Gi Kim | 3 | 403 | 55.43 |