Title
Protein-Protein Interaction Network Querying by a "Focus and Zoom" Approach
Abstract
We propose an approach to network querying in protein-protein interaction networks based on bipartite graph weighted matching. An algorithm is presented that first "focuses" the potentially relevant portion of the target graph by performing a global alignment of this one with the query graph, and then "zooms" on the actual matching nodes by considering their topological arrangement, hereby obtaining a (possibly) approximated occurrence of the query graph within the target graph. Approximation is related to node insertions, node deletions and edge deletions possibly intervening in the query graph. The technique manages networks of arbitrary topology. Moreover, edge labels are used to represent and manage the reliability of involved interactions. Some preliminary experimental analysis is also accounted for in the paper.
Year
DOI
Venue
2008
10.1007/978-3-540-70600-7_25
BIOINFORMATICS RESEARCH AND DEVELOPMENT, PROCEEDINGS
Keywords
Field
DocType
experimental analysis,bipartite graph
Biconnected graph,Computer science,Theoretical computer science,Artificial intelligence,Voltage graph,Adjacency matrix,Folded cube graph,Simplex graph,Null graph,Bioinformatics,Butterfly graph,Machine learning,Graph (abstract data type)
Conference
Volume
ISSN
Citations 
13
1865-0929
6
PageRank 
References 
Authors
0.41
10
4
Name
Order
Citations
PageRank
Valeria Fionda113018.53
Luigi Palopoli21387185.69
Simona Panni3746.80
Simona E. Rombo419222.21