Paper Info
Title
On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field.
Abstract
High field (≥7 T) MRI studies based on signal phase have been used to improve visualization of the fine structure of the brain, most notably the major white matter fiber bundles, the gray–white matter subdivision, and the laminar cortical architecture. The observed contrast has been attributed in part to local variations in magnetic susceptibility arising from iron in storage proteins and tissue lipid. Another contribution could come from the paramagnetic blood constituent deoxy-hemoglobin, the tissue concentration of which may vary through local variations in vascular density. To investigate this possibility, we examined phase contrast between gray and white matter in rats after intravenous administration of a superparamagnetic contrast agent at various dosages. At the maximum dosage (3 mg Fe/kg), which resulted in an estimated paramagnetic susceptibility shift 4–8 times larger than deoxy-hemoglobin, we observed a negligible increase in phase contrast between gray and white matter. This result suggests that endogenous deoxy-hemoglobin has no significant contribution to phase contrast between gray and white matter.
Year
DOI
Venue
2010
10.1016/j.neuroimage.2009.07.017
NeuroImage
Keywords
Field
DocType
Phase contrast image,Deoxy-hemoglobin,High field,USPIO,Iron oxide nano-particle
Magnetic susceptibility,Hemoglobin,White matter,Superparamagnetism,Paramagnetism,Cognitive psychology,Psychology,Cerebral cortex,Corpus callosum,Nuclear magnetic resonance,Pathology,Magnetic resonance imaging
Journal
Volume
Issue
ISSN
49
1
1053-8119
Citations 
PageRank 
References 
16
1.74
5
Authors
5
Name
Order
Citations
PageRank
Jongho Lee1716.17
Yoshiyuki Hirano2738.48
Masaki Fukunaga331927.13
Afonso C. Silva422018.38
Jeff H. Duyn583948.39