Title
Comparing best-first search and dynamic programming for optimal multiple sequence alignment
Abstract
Sequence alignment is an important problem in computational biology. We compare two different approaches to the problem of optimally aligning two or more character strings: bounded dynamic programming (BDP), and divide-and-conquer frontier search (DCFS). The approaches are compared in terms of time and space requirements in 2 through 5 dimensions with sequences of varying similarity and length. While BDP performs better in two and three dimensions, it consumes more time and memory than DCFS for higher-dimensional problems.
Year
Venue
Keywords
2003
IJCAI
character string,optimal multiple sequence alignment,important problem,bounded dynamic programming,best-first search,varying similarity,sequence alignment,different approach,computational biology,space requirement,divide-and-conquer frontier search,higher-dimensional problem,three dimensions,multiple sequence alignment,divide and conquer
Field
DocType
Citations 
Sequence alignment,Dynamic programming,Computer science,Spacetime,Theoretical computer science,Multiple sequence alignment,Best-first search,Bounded function
Conference
7
PageRank 
References 
Authors
0.80
10
3
Name
Order
Citations
PageRank
Heath Hohwald11156.75
Ignacio Thayer2493.12
Richard E. Korf33568729.78