Paper Info
Title
Human brain myelination from birth to 4.5 years.
Abstract
The myelination of white matter from birth through the first years of life has been studied qualitatively and it is well know the myelination occurs in a orderly and predictable manner, proceeding in a caudocranial direction, from deep to superficial and from posterior to anterior. Even if the myelination is a continuous process, it is useful to characterize myelination evolution in normal brain development in order to better study demyelinating diseases. The quantification of myelination has only been studied for neonates. The original contribution of this study is to develop a method to characterize and visualize the myelination pattern using MRI data from a group of normal subjects from birth to just over 4 years of age. The method includes brain extraction and tissue classification in addition to the analysis of T2 relaxation times to attempt to separate myelinated and unmyelinated white matter. The results agree previously published qualitative observations.
Year
DOI
Venue
2008
10.1007/978-3-540-85990-1_22
MICCAI (2)
Keywords
Field
DocType
unmyelinated white matter,normal brain development,mri data,brain extraction,better study,white matter,human brain myelination,myelination pattern,t2 relaxation time,myelination evolution,normal subject,relaxation time,brain development
Central gray matter,Brain development,Anatomy,White matter,Computer science,Human brain
Conference
Volume
Issue
ISSN
11
Pt 2
0302-9743
Citations 
PageRank 
References 
2
0.39
2
Authors
5
Name
Order
Citations
PageRank
Berengere Aubert-Broche116614.12
Vladimir Fonov247820.32
I Leppert320.39
G Bruce Pike4699132.31
D. Louis Collins53915403.90